Lactate Dehydrogenase Serum
Category: Lactate Dehydrogenase Serum
Also known as: LD, Lactate dehydrogenase, Lactic dehydrogenase, Total LDH, and LDH isoenzymes.
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Lactate dehydrogenase (LDH or LD) is an enzyme found in almost all body tissues, but only in a small amount in the blood. LDH is found in the bloodstream when cells are damaged. Because of this, LDH test can be used as a general marker of cells damage.
Level of LDH may be measured either as a total LDH or as LDH isoenzymes. A total LDH level is an overall measurement of five different LDH isoenzymes (slightly different molecular versions of the LDH enzyme).
Each of the five LDH isoenzymes tends to be concentrated in specific body tissues. Then, measurements of the individual LDH isoenzyme levels can help determine the disease or by identifying the organs and tissues involved.
The five isoensymes and they common location are:
• LDH-1, heart, red cells, kidney, germ cells
• LDH-2, heart, red blood cells, kidney
• LDH-3, lungs and other tissues
• LDH-4, white blood cells, lymph nodes, muscle, liver
• LDH-5, liver, skeletal muscle
LDH-2 usually is present on a bigger pertentage on the total LDH test.
Its concentration is measured by means of analysis of a blood sample drawn from the vein in the arm.
Purpose of the test
This test helps identifying the cause and location of tissue damage in the body and to monitor its progress.
It is prescribed, along with other tests, when the doctor suspects an acute or chronic condition that is causing tissue or cellular destruction, in order to identify the source of the damage.
Reference range values
113 – 226 U/L
High levels of LDH and changes in the ratio of the LDH isoenzymes usually indicate some type of tissue damage.
Elevated levels of LDH may be seen with:
• Cerebrovascular accident (CVA, stroke)
• Drugs: anesthetics, aspirin, narcotics, procainamides, alcohol
• Hemolytic anemias
• Pernicious anemias (megaloblastic anemais)
• Infectious mononucleosis (Mono)
• Intestinal and pulmonary infarction
• Kidney disease
• Liver disease
• Muscular dystrophy
• Lymphoma or other cancers
Low and normal levels of LDH do not usually indicate a problem. Low levels can be seen when a patient ingests large amounts of vitamin C).