Osteocalcin

Category:

Osteocalcin

Description

Alternative name: Bone g1a protein measurement.
Osteocalcin is a major protein found in bone. Small amounts of this protein are found in the bloodstream.
By analysing the Osteocalcin level in the blood, we can have an estimation of the presence of the protein in the bones.
This analysis is normally used to help evaluate bone formation disorders. Also it is used when a secondary malignant neoplasm of the bone is suspected. Finally it may also be used to monitor postmenopausal women who are at risk for osteoporosis.

Its concentration is measured by means of analysis of a blood sample drawn from the vein in the arm.

Purpose of the test

This test measures the level of osteocalcin in blood.   It is presecribed when a bone formation problem is foreseen.  Also to check for bone tumor metastasis and to monitor osteoporosis.

Reference range values
The following are considered normal results for this test:
• Adult male: 3-13 mcg/L
• Adult premenopausal female: 0.4-8.2 mcg/L
• Adult postmenopausal female: 1.5-11 mcg/L
• Children, 2 to 17 years: 2.8-41 mcg/L
• Neonates: 20-40 mcg/L
In adult males, levels vary over a 24h period  in a 5- to 10-mc/L. Circulating levels are lowest in late afternoon and peak at night.

Abnormal findings

High Osteocalcin levels in blood are found with:
o Adolescent growth spurts (40-80 mcg/L in boys)
o Chronic renal failure
o Hyperthyroidism
Low Osteocalcin levels in blood are found with:
o Pregnancy
o Cirrhosis