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Estrogens, Total

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Description
 
Estrogen tests may be used for a variety of reasons:
  • Estrone levels may be elevated in patients with polycystic ovarian syndrome and endometriosis. Tests may be used to aid in the diagnosis of an ovarian tumor, Turner's syndrome, and hypopituitarism. In males, it may help in the diagnosis of the cause of gynecomastia or in the detection of estrogen-producing tumors.
  • Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy. A doctor may sometimes order a total estrogens test. This test measures estrone and estradiol together but does not measure estriol.
  • Estriol may sometimes be ordered serially to help monitor a high risk pregnancy. When it is used this way, each sample should be drawn at the same time each day. An unconjugated estriol test, one that measures estriol that is not bound to a protein, is one of the components of the triple or quad screen. Decreased levels have been associated with various genetic disorders including Down syndrome, neural tube defects, and adrenal abnormalities. It is ordered during pregnancy, along with maternal alpha-fetoprotein (AFP maternal), human chorionic gonadotropin (hCG), and inhibin-A tests, to assess the risk of carrying a fetus with certain abnormalities.

 

 

Reference Interval:

 

Age

Male

(pg/mL)

Female

(pg/mL)

0-10 y

0-25

0-25

Adults

40-115

Female cycle:

Castrate: <40

1-10 d: 61-394

11-20 d: 122-437

21-30 d: 156-350

Postmenopausal: <40

HMG treatment for ovulation induction: 400-800

Tanner Stage

I

10-38

10-46

II

17-45

22-63

III

22-55

24-110

IV

27-80

40-180

V

25-80

60-280

 

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