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Hemoglobinopathy (Hgb) Fractionation Profile

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Description

The Hemoglobinopathy (Hgb) Fractionation Profile is used to help diagnose thalassemias and hemoglobin variants

Test Includes:
Identification and relative percentages of hemoglobins (A, A2, F, S, C) including variants, if present; hemoglobin solubility; interpretation.
Reference Interval:

Hb A: 94% to 98% (adults)

Hb F:

• 1 day: 69.7% to 84.3%

• 5 days: 71.0% to 82.6%

• 3 weeks: 62.7% to 77.3%

• 6-9 weeks: 41.9% to 63.9%

• 3-4 months: 7.2% to 39.2%

• 6 months: 2.5% to 6.9%

• 8-12 months: 0.6% to 2.6%

• >1 year: 0% to 2%

Hb S, D, G: 0-0%

Hb C, E, O: 0-0%

Hb A2: 0.7% to 3.1%

Hemoglobin solubility: Negative

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