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Insulin-like Growth Factor Binding Protein 3 (IGF-BP3)

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Description

Also known as: IGF BP-3

Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and are thought to be important in tumour growing. Circulating concentrations of IGF-I might be associated with an increased risk of cancer, and IGFBP-3 concentrations could be associated with a decreased cancer risk.

Its concentration is measured by means of analysis of a blood sample drawn from the vein in the arm.

Purpose of the test

Insulin-like growth factor (IGF)-binding proteins (IGFBPs) regulate the actions of the IGFs by influencing interactions between the IGFs and the IGF receptors. IGFBP-3, one of the six known species of IGFBPs, is the predominant IGFBP in serum and is present with breast cancer . Compared with estrogen receptor (ER)-positive samples, ER-negative breast cancer cell lines and tumors express higher levels of IGFBP-3. Therefore, expression of IGFBP-3 may be relevant in breast cancer biology.

Reference range values

Age	Male	Female
0-1 year 2-3 years 4-5 years 6-7 years 8-9 years 10-11 years 12-13 years 14-15 years 16-17 years 18-19 years 20-24 years 25-29 years 30-34 years 35-39 years 40-44 years 45-49 years 50-54 years 55-59 years 60-64 years 65 years and older	1444-4408 ng/mL 1586-4444 ng/mL 1706-5082 ng/mL 1838-4468 ng/mL 1932-5858 ng/mL 1828-6592 ng/mL 2134-6598 ng/mL 2330-6550 ng/mL 2380-6400 ng/mL 2340-6632 ng/mL 2404-5948 ng/mL 2614-5792 ng/mL 2500-5806 ng/mL 2474-5208 ng/mL 2360-5560 ng/mL 2314-5700 ng/mL 2528-5050 ng/mL 2482-5460 ng/mL 2592-4770 ng/mL 2698-5688 ng/mL	1176-4916 ng/mL 1870-5426 ng/mL 2092-4936 ng/mL 2188-4996 ng/mL 2072-5504 ng/mL 2456-6992 ng/mL 2838-6846 ng/mL 2654-6680 ng/mL 2756-6908 ng/mL 2700-6492 ng/mL 3032-5992 ng/mL 2926-5858 ng/mL 2878-6650 ng/mL 2786-6084 ng/mL 2514-6014 ng/mL 2838-4954 ng/mL 2562-5596 ng/mL 2574-5914 ng/mL 2684-5130 ng/mL 2462-5274 ng/mL
Tanner Stage I Tanner Stage II Tanner Stage III Tanner Stage IV & V	1878-6190 ng/mL 2112-6208 ng/mL 2372-6602 ng /mL 2336-6414 ng/mL	2314-6086 ng/mL 2732-6738 ng/mL 2870-7068 ng/mL 2756-7232 ng/mL

Abnormal findings

The lower the results from the normal range, the higher the probability of presence of a tumour.

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